Conessine

CAT: 0931-T20712-05Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0931-T20712-05Size:100 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

546-06-5

Target

FOXO, Parasite, MDM-2/p53, NF-κB, Histamine Receptor, Antibacterial

Related Pathways

NF-κB, Apoptosis, Microbiology/Virology, GPCR/G Protein, Neuroscience, Immunology/Inflammation

Purity

0.9986

Bioactivity

Conessine (Conessinum), a steroidal alkaloid isolated from Holarrhena floribunda, interacts with the histamine H3 receptor and has anti-malarial activity.

Smiles

[H][C@]12CC[C@@]3([H])[C@]4([H])CC=C5C[C@H](CC[C@]5(C)[C@@]4([H])CC[C@]13CN(C)[C@H]2C)N(C)C

Molecular Formula

C24H40N2

Molecular Weight

356.59

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Conessine

Conessine is a steroid alkaloid that is con-5-enine substituted by a N,N-dimethylamino group at position 3. It has been isolated from the plant species of the family Apocynaceae. It has a role as an antibacterial agent, an antimalarial, a H3-receptor antagonist and a plant metabolite. It is a steroid alkaloid and a tertiary amino compound. It is functionally related to a conanine.

CAS Number	546-06-5
PubChem CID	441082
IUPAC Name	(1R,2S,5S,6S,9R,12S,13R,16S)-N,N,6,7,13-pentamethyl-7-azapentacyclo[10.8.0.02,9.05,9.013,18]icos-18-en-16-amine
Molecular Formula	C24H40N2
Molecular Weight	356.6
XLogP	4.9
Topological Polar Surface Area	6.5
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Heavy Atom Count	26
Formal Charge	0
Complexity	609

SMILES

C[C@H]1[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3CC=C5[C@@]4(CC[C@@H](C5)N(C)C)C)CN1C

InChI

InChI=1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1

InChIKey

GPLGAQQQNWMVMM-MYAJQUOBSA-N

Chemical Structure

2D Structure

CAS: 546-06-5

CID: 441082

Formula: C24H40N2

MW: 356.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	356.6
XLogP3	4.9
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	356.319149284
Monoisotopic Mass	356.319149284
Topological Polar Surface Area	6.5 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	609
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
FC57645-01	Conessine
GTR19223675-01	Conessine hydrobromide
HY-107566A	Conessine (dihydrobromide)

Conessine

Chemical Information

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