Epimedin A

• Description:

  Epimedin A, one of the main flavonoid active components in Herba Epimedii, is orally active. Epimedin A can inhibit osteoclastogenesis, differentiation, and bone resorption. Epimedin A also possesses anti-inflammatory activity. Epimedin A can be used in the research of osteoporosis and inflammatory diseases[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Akt; Caspase; Heme Oxygenase (HO) ; Interleukin Related; Keap1-Nrf2; NF-κB; NOD-like Receptor (NLR) ; PI3K; SOD

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

• Field of Research:

  Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/Epimedin-A.html

• Concentration:

  10mM

• Purity:

  99.43

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(O)=C(C(C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O[C@@]4([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)=C(C5=CC=C(OC)C=C5)O6)=O)C6=C2C/C=C(C)/C)[C@@H]1O

• Molecular Formula:

  C39H50O20

• Molecular Weight:

  838.80

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Zhang HF, et al. Simultaneous extraction of epimedin A, B, C and icariin from Herba Epimedii by ultrasonic technique. Ultrason Sonochem. 2008 Apr;15 (4) :376-85.|[2]Li J, et al. Epimedin A inhibits the PI3K/AKT/NF-κB signalling axis and osteoclast differentiation by negatively regulating TRAF6 expression. Mol Med. 2024 Aug 16;30 (1) :125.|[3]Balaha MF, et al. Epimedin A ameliorates DNFB-induced allergic contact dermatitis in mice: Role of NF-κB/NLRP3-driven pyroptosis, Nrf2/HO-1 pathway, and inflammation modulation. Life Sci. 2022 Aug 1;302:120653.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Caspase 1; Caspase 8; HO-1; IL-1; IL-6; NLRP3

• CAS Number:

  [110623-72-8]