Amakusamine

• Description :

  Amakusamine inhibits the receptor activator of nuclear factor-κB ligand (RANKL) -induced formation of multinuclear osteoclasts with an IC50 value of 10.5 μM in RAW264.7 cells.

• UNSPSC :

  12352005

• Target :

  RANKL/RANK

• Type :

  Natural Products

• Related Pathways :

  NF-κB

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/amakusamine.html

• Solubility :

  10 mM in DMSO

• Smiles :

  BrC1=C2OCOC2=C(C3=C1C=CN3)Br

• Molecular Formula :

  C9H5Br2NO2

• Molecular Weight :

  318.95

• References & Citations :

  [1]Maeyama Y, et al. Amakusamine from a Psammocinia sp. Sponge: Isolation, Synthesis, and SAR Study on the Inhibition of RANKL-Induced Formation of Multinuclear Osteoclasts. J Nat Prod. 2021 Oct 22;84 (10) :2738-2743.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [2923661-84-9]