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Momelotinib

CAT: 0931-T1849-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T1849-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1056634-68-4
Target
JAK, Autophagy, Apoptosis
Related Pathways
JAK/STAT signaling, Chromatin/Epigenetic, Stem Cells, Angiogenesis, Apoptosis, Tyrosine Kinase/Adaptors, Autophagy
Purity
0.9956
Bioactivity
Momelotinib (LM-1149) is an orally bioavailable small-molecule inhibitor of Janus kinases 1 and 2 (JAK1/2) with IC50 of 11 nM/18 nM. JAK1/2 inhibitor CYT387 competes with JAK1/2 for ATP binding, which may result in inhibition of JAK1/2 activation, inhibition of the JAK-STAT signaling pathway, and so the induction of apoptosis and a reduction of tumor cell proliferation in JAK1/2-expressing tumor cells.
Smiles
O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Molecular Formula
C23H22N6O2
Molecular Weight
414.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GW7607-10mgMomelotinib
GSB63606-01Momelotinib sulfate
MBS3846085-01Momelotinib Mesylate
JH920534Momelotinib Dihydrochloride
GTR19209026-01Momelotinib HCl
C08367-50mgMomelotinib (CYT387)
HY-10963Momelotinib (mesylate)
AR-M05041-01Momelotinib-d4
CS-O-53329Momelotinib-d8
HY-10962-01Momelotinib (sulfate)

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