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Penpaxilloids A

CAT: 0804-HY-N12761Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N12761Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Penpaxilloids A (Compound 1) is a non-competitive inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 8.60 μM. Penpaxilloids A can be isolated from the fungus Penicillium sp. ZYX-Z-143. Penpaxilloids A is also an α-glucosidase (α-glucosidase) inhibitor with anti-inflammatory activity[1].
UNSPSC
12352005
Target
Glycosidase; Phosphatase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/penpaxilloids-a.html
Solubility
10 mM in DMSO
Smiles
O=C(CC1)N2[C@H]1O[C@@]3(C([C@@]([C@](CC[C@@](O[C@@H]4C(C)(O)C)([H])C5=CC4=O)(C)[C@@]5(O)CC6)(C)[C@]6([H])C3)=O)C7=CC=CC=C72
Molecular Formula
C31H37NO7
Molecular Weight
535.63
References & Citations
[1]Dai LT, et al. Anti-diabetic and anti-inflammatory indole diterpenes from the marine-derived fungus Penicillium sp. ZYX-Z-143. Bioorg Chem. 2024 Apr;145:107205.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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