Nintedanib

• Target :

  PDGFR|||FLT|||VEGFR|||FGFR|||Src

• Related Pathways :

  Tyrosine Kinase/Adaptors|||Angiogenesis

• Purity :

  0.9992

• Bioactivity :

  Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFR?, and PDGFR? (IC50=59/65 nM) . Nintedanib has antitumor activity and inhibits tumor growth by inhibiting angiogenesis.

• Smiles :

  COC(c1cc2c(/C(C(N2)=O)=C(c3ccccc3)/Nc4ccc(N(C(CN5CCN(CC5)C)=O)C)cc4)cc1)=O

• Molecular Formula :

  C31H33N5O4

• Molecular Weight :

  539.62

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  656247-17-5