Products for Research Use Only
RegisterLogin

GSK503

CAT: 0931-T1775-02Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T1775-02Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1346572-63-1
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Purity
0.9989
Bioactivity
GSK-503, a potent EZH2 inhibitor, has potential antitumor activity.
Smiles
CC(C)n1cc(C)c2c(cc(cc12)-c1ccc(nc1)N1CCN(C)CC1)C(=O)NCc1c(C)cc(C)[nH]c1=O
Molecular Formula
C31H38N6O2
Molecular Weight
526.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide

GSK503 is a potent and specific inhibitor of EZH2 methyltransferase.

CAS Number1346572-63-1
PubChem CID67469117
IUPAC NameN-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-methyl-6-[6-(4-methylpiperazin-1-yl)-3-pyridinyl]-1-propan-2-ylindole-4-carboxamide
Molecular FormulaC31H38N6O2
Molecular Weight526.7
XLogP3.8
Topological Polar Surface Area82.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count39
Formal Charge0
Complexity984
SMILES
CC1=CC(=C(C(=O)N1)CNC(=O)C2=C3C(=CN(C3=CC(=C2)C4=CN=C(C=C4)N5CCN(CC5)C)C(C)C)C)C
InChI
InChI=1S/C31H38N6O2/c1-19(2)37-18-21(4)29-25(30(38)33-17-26-20(3)13-22(5)34-31(26)39)14-24(15-27(29)37)23-7-8-28(32-16-23)36-11-9-35(6)10-12-36/h7-8,13-16,18-19H,9-12,17H2,1-6H3,(H,33,38)(H,34,39)
InChIKey
HRDQQHUKUIKFHT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide
CAS: 1346572-63-1
CID: 67469117
Formula: C31H38N6O2
MW: 526.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight526.7
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass526.30562448
Monoisotopic Mass526.30562448
Topological Polar Surface Area82.5 Ų
Heavy Atom Count39
Formal Charge0
Complexity984
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T70015-01GSK563
T3537-01GSK583
T11480-01GSK205
T15427-01GSK2033
T25469-01GSK223
T6853-01GSK591
T27491-01GSK730
T38626GSK143
T208239-01GSK023
T7388-01GSK805

Alternative Products

CatalogName
MBS384837-01GSK503
451496-01GSK503-d8
A15549-100GSK503 100mg
A15549-10GSK503 10mg
A15549-5GSK503 5mg
A15549-1GSK503 1mg
A15549-500GSK503 500mg
A15549-50GSK503 50mg
A15549-25GSK503 25mg
A15549-2GSK503 2mg

Popular Products