W-54011

• Target :

  Complement System|||ROS|||Reactive Oxygen Species

• Related Pathways :

  Metabolism|||Immunology/Inflammation|||NF-?B

• Purity :

  0.968

• Bioactivity :

  W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki = 2.2 nM) . W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils (IC50s = 3.1 nM, 2.7 nM, and 1.6 nM, respectively) .

• Smiles :

  Cl.COc1ccc2CCCC(C(=O)N(Cc3ccc(cc3)N(C)C)c3ccc(cc3)C(C)C)c2c1

• Molecular Formula :

  C30H37ClN2O2

• Molecular Weight :

  493.08

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  405098-33-1