W-54011

• Target:

  Complement System|||ROS|||Reactive Oxygen Species

• Related Pathways:

  Metabolism|||Immunology/Inflammation|||NF-?B

• Purity:

  0.968

• Bioactivity:

  W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki = 2.2 nM) . W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils (IC50s = 3.1 nM, 2.7 nM, and 1.6 nM, respectively) .

• Smiles:

  Cl.COc1ccc2CCCC (C (=O) N (Cc3ccc (cc3) N (C) C) c3ccc (cc3) C (C) C) c2c1

• Molecular Formula:

  C30H37ClN2O2

• Molecular Weight:

  493.08

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  405098-33-1