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W-54011

CAT: 0931-T17250-01Size: 1 mgDry Ice: NoHazardous: No
CAT#: T17250-01Size: 1 mg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
405098-33-1
Target
Complement System|||ROS|||Reactive Oxygen Species
Related Pathways
Metabolism|||Immunology/Inflammation|||NF-?B
Purity
0.968
Bioactivity
W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki = 2.2 nM) . W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils (IC50s = 3.1 nM, 2.7 nM, and 1.6 nM, respectively) .
Smiles
Cl.COc1ccc2CCCC(C(=O)N(Cc3ccc(cc3)N(C)C)c3ccc(cc3)C(C)C)c2c1
Molecular Formula
C30H37ClN2O2
Molecular Weight
493.08
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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