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VER-246608

CAT: 0931-T17224-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T17224-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1684386-71-7
Target
PDK, Dehydrogenase
Related Pathways
Metabolism, PI3K/Akt/mTOR signaling
Purity
0.9888
Bioactivity
VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively) .VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin.
Smiles
Cc1cnc(Cl)nc1-c1ccc(cc1)N(Cc1ccc(CNC(=O)C(F)F)cc1)C(=O)c1ccc(O)cc1O
Molecular Formula
C28H23ClF2N4O4
Molecular Weight
552.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
HY-12492-01VER-246608
6604/50VER 246608
A22015-100VER-246608 100mg
A22015-25VER-246608 25mg

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