TAK-243

• Target:

  NF-?B|||Apoptosis|||E1/E2/E3 Enzyme

• Related Pathways:

  Apoptosis|||NF-?B|||Ubiquitination

• Purity:

  0.9893

• Bioactivity:

  TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM), blocking ubiquitin binding and disrupting both mono-ubiquitin signaling and overall protein ubiquitination. TAK-243 exhibits antitumor activity and promotes apoptosis.

• Smiles:

  NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2cccc(SC(F)(F)F)c2)[C@H](O)[C@@H]1O

• Molecular Formula:

  C19H20F3N5O5S2

• Molecular Weight:

  519.52

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1450833-55-2