TAK-243

• Target :

  NF-?B|||Apoptosis|||E1/E2/E3 Enzyme

• Related Pathways :

  Apoptosis|||NF-?B|||Ubiquitination

• Purity :

  0.9893

• Bioactivity :

  TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM), blocking ubiquitin binding and disrupting both mono-ubiquitin signaling and overall protein ubiquitination. TAK-243 exhibits antitumor activity and promotes apoptosis.

• Smiles :

  NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2cccc(SC(F)(F)F)c2)[C@H](O)[C@@H]1O

• Molecular Formula :

  C19H20F3N5O5S2

• Molecular Weight :

  519.52

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1450833-55-2