Donafenib

• Target:

  FLT|||Ferroptosis|||VEGFR|||Apoptosis|||Autophagy|||Raf

• Related Pathways:

  MAPK|||Angiogenesis|||Autophagy|||Tyrosine Kinase/Adaptors|||Apoptosis

• Purity:

  0.9988

• Bioactivity:

  Donafenib (Bay 43-9006 (D3) ) is a deuterium-labeled Sorafenib which is a multikinase inhibitor (IC50s: 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively) .

• Smiles:

  [2H]C([2H])([2H])NC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1

• Molecular Formula:

  C21H13ClD3F3N4O3

• Molecular Weight:

  467.84

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1130115-44-4