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Quarfloxin

CAT: 0931-T16703-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T16703-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
865311-47-3
Target
DNA/RNA Synthesis
Related Pathways
DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Purity
0.9977
Bioactivity
Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA template.
Smiles
CN1CCC[C@H]1CCNC(=O)c1cn2c3cc4ccccc4cc3oc3c(N4CCC(C4)c4cnccn4)c(F)cc(c23)c1=O
Molecular Formula
C35H33FN6O3
Molecular Weight
604.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C