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Vandetanib

CAT: 0931-T1656-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T1656-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
443913-73-3
Target
Apoptosis, VEGFR, EGFR, Autophagy
Related Pathways
Autophagy, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis, Apoptosis
Purity
>99.99%
Bioactivity
Vandetanib (ZD6474) is a potent inhibitor of VEGFR2 (IC50: 40 nM) . It also inhibits VEGFR3 and EGFR.
Smiles
COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Molecular Formula
C22H24BrFN4O2
Molecular Weight
475.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Vandetanib

Vandetanib is a quinazoline that is 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline bearing additional methoxy and 4-bromo-2-fluorophenylamino substituents at positions 6 and 4 respectively. Used for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It is a member of piperidines, a secondary amine, an aromatic ether, an organobromine compound, an organofluorine compound and a member of quinazolines.

CAS Number443913-73-3
PubChem CID3081361
IUPAC NameN-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
Molecular FormulaC22H24BrFN4O2
Molecular Weight475.4
XLogP4.9
Topological Polar Surface Area59.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count30
Formal Charge0
Complexity539
SMILES
CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC
InChI
InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
InChIKey
UHTHHESEBZOYNR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Vandetanib
CAS: 443913-73-3
CID: 3081361
Formula: C22H24BrFN4O2
MW: 475.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight475.4
XLogP34.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass474.10667
Monoisotopic Mass474.10667
Topological Polar Surface Area59.5 Ų
Heavy Atom Count30
Formal Charge0
Complexity539
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
FV28668-01Vandetanib

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