Pladienolide B

• Target:

  Apoptosis

• Related Pathways:

  Apoptosis

• Purity:

  0.9827

• Bioactivity:

  Pladienolide B is a potent spliceosome inhibitor, a macrolide isolated from Streptomyces obtusususus Mer-12, which targets the SF3B1 subunit of the spliceosome.Pladienolide B exerts its antitumor effects by inhibiting pre-mRNA splicing and inducing necrosis.Pladienolide B possesses antitumor activity and can be used to study leukemia and lymphoid tumors. Pladienolide B has antitumor activity and can be used to study leukemia and lymphoid tumors.

• Smiles:

  C ([C@@H] (/C=C/C=C (\C) /[C@@H]1[C@@H] (C) /C=C/[C@H] (OC (C) =O) [C@] (C) (O) CC[C@@H] (O) CC (=O) O1) C) [C@@H]2[C@@] ([C@@H] ([C@H] (CC) O) C) (O2) [H]

• Molecular Formula:

  C30H48O8

• Molecular Weight:

  536.7

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  445493-23-2