PKR-IN-C16

• Target :

  Apoptosis|||Others

• Related Pathways :

  Others|||Apoptosis

• Purity :

  0.9948

• Bioactivity :

  PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. PKR-IN-C16 protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress.

• Smiles :

  O=C1Nc2ccc3ncsc3c2\C1=C\c1cnc[nH]1

• Molecular Formula :

  C13H8N4OS

• Molecular Weight :

  268.29

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  608512-97-6