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PKR-IN-C16

CAT: 0931-T16550-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T16550-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
608512-97-6
Target
Apoptosis, Others
Related Pathways
Others, Apoptosis
Purity
0.9948
Bioactivity
PKR-IN-C16 is a specific protein kinase (PKR) inhibitor. PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. PKR-IN-C16 protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress.
Smiles
O=C1Nc2ccc3ncsc3c2\C1=C\c1cnc[nH]1
Molecular Formula
C13H8N4OS
Molecular Weight
268.29
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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