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Pico145

CAT: 0931-T16532-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T16532-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1628287-16-0
Target
TRP/TRPV Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.9906
Bioactivity
Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, specifically inhibiting () -englerin A-activated TRPC4/TRPC5 channels with IC50s of 0.349 and 1.3 nM in cells, while showing no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, or TRPM8.
Smiles
Cn1c2nc(Oc3cccc(OC(F)(F)F)c3)n(Cc3ccc(Cl)cc3)c2c(=O)n(CCCO)c1=O
Molecular Formula
C23H20ClF3N4O5
Molecular Weight
524.88
Shipping Conditions
Ice Packs
Storage Temperature
-20°C