PF-5006739

• Target:

  Casein Kinase

• Related Pathways:

  Stem Cells|||Metabolism

• Bioactivity:

  PF-5006739 is an effective and selective inhibitor of CK1?/? (IC50s: 3.9 nM and 17.0 nM, respectively) . PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1?/? and high kinome selectivity. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity. PF-5006739 decreases opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner.

• Smiles:

  Nc1nccc (n1) -c1c (ncn1C1CCN (Cc2ccon2) CC1) -c1ccc (F) cc1

• Molecular Formula:

  C22H22FN7O

• Molecular Weight:

  419.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1293395-67-1