PF-5006739

• Target :

  Casein Kinase

• Related Pathways :

  Stem Cells|||Metabolism

• Bioactivity :

  PF-5006739 is an effective and selective inhibitor of CK1?/? (IC50s: 3.9 nM and 17.0 nM, respectively) . PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1?/? and high kinome selectivity. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity. PF-5006739 decreases opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner.

• Smiles :

  Nc1nccc(n1)-c1c(ncn1C1CCN(Cc2ccon2)CC1)-c1ccc(F)cc1

• Molecular Formula :

  C22H22FN7O

• Molecular Weight :

  419.45

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1293395-67-1