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PF-3644022

CAT: 0931-T16501-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T16501-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1276121-88-0
Target
Serine Protease, MAPK, p38 MAPK
Related Pathways
MAPK, Proteases/Proteasome
Purity
0.9912
Bioactivity
PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM) . PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) (IC50s: 53 nM and 5.0 nM, respectively) .
Smiles
C[C@@H]1CNc2c(sc3ccc4nc(ccc4c23)-c2ccc(C)nc2)C(=O)N1
Molecular Formula
C21H18N4OS
Molecular Weight
374.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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B5549-10PF-3644022
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A11282-100PF-3644022 100mg

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