PF-3644022

• Target:

  Serine Protease|||MAPK|||p38 MAPK

• Related Pathways:

  MAPK|||Proteases/Proteasome

• Purity:

  0.9912

• Bioactivity:

  PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM) . PF-3644022 potently inhibits TNF? production and has an anti-inflammatory effect. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) (IC50s: 53 nM and 5.0 nM, respectively) .

• Smiles:

  C[C@@H]1CNc2c(sc3ccc4nc(ccc4c23)-c2ccc(C)nc2)C(=O)N1

• Molecular Formula:

  C21H18N4OS

• Molecular Weight:

  374.46

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1276121-88-0