PF-04995274

• Target:

  5-HT Receptor

• Related Pathways:

  Neuroscience|||GPCR/G Protein

• Purity:

  0.9955

• Bioactivity:

  PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has an EC50 range of 0.26-0.47 nM for human 5-HT4A/4B/4D/4E (Ki range of 0.15-0.46 nM) . It also has an EC50 range of 0.59-0.65 nM for rat 5-HT4S/4L/4E (Ki of 0.30 nM for rat 5-HT4S) .

• Smiles:

  OC1 (CN2CCC (COc3noc4cccc (O[C@@H]5CCOC5) c34) CC2) CCOCC1

• Molecular Formula:

  C23H32N2O6

• Molecular Weight:

  432.51

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1331782-27-4