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PF-03715455

CAT: 0931-T16477-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T16477-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1056164-52-3
Target
P38 MAPK
Related Pathways
MAPK
Bioactivity
PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM) . PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respective IC50: 0.88 and 23 nM) . PF-03715455 has the potential for the treatment of COPD.
Smiles
S(C1=CN2C(=NN=C2C=C1)C3=C(SCCO)C=CC=C3)C4=C(CNC(NC=5N(N=C(C(C)(C)C)C5)C6=CC(Cl)=C(O)C=C6)=O)C=CC=C4
Molecular Formula
C35H34ClN7O3S2
Molecular Weight
700.27
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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