PF-03715455

• Target:

  P38 MAPK

• Related Pathways:

  MAPK

• Bioactivity:

  PF-03715455 potently inhibits LPS-induced TNF? production in human whole blood (IC50=1.7 nM) . PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38? over p38? (respective IC50: 0.88 and 23 nM) . PF-03715455 has the potential for the treatment of COPD.

• Smiles:

  S(C1=CN2C(=NN=C2C=C1)C3=C(SCCO)C=CC=C3)C4=C(CNC(NC=5N(N=C(C(C)(C)C)C5)C6=CC(Cl)=C(O)C=C6)=O)C=CC=C4

• Molecular Formula:

  C35H34ClN7O3S2

• Molecular Weight:

  700.27

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1056164-52-3