Nigericin

• Target:

  Sodium Channel|||Apoptosis|||NOD-like Receptor (NLR) |||Caspase|||Pyroptosis|||Potassium Channel|||Antibiotic|||Wnt/beta-catenin|||Antibacterial

• Related Pathways:

  Apoptosis|||Stem Cells|||Proteases/Proteasome|||Cytoskeletal Signaling|||Microbiology/Virology|||Membrane transporter/Ion channel|||Immunology/Inflammation

• Purity:

  0.985

• Bioactivity:

  Nigericin is a polyether antibiotic with potent antimicrobial, antimalarial, anticoronaviral and anticancer activities. It is capable of promoting cellular potassium efflux, inducing Caspase-1/GSDMD and Caspase-3-mediated cellular pyroptosis and apoptosis in triple-negative breast cancer, and inducing apoptosis in PEL (primary exudative lymphoma) cells through mitochondrial dysfunction and Wnt/?-catenin signaling downregulation.

• Smiles:

  C[C@H]1[C@]2(O[C@@](C)(C1)[C@@]3(O[C@@](C)(CC3)[C@@]4(O[C@](C[C@@H]4C)([C@]5(O[C@](CO)(O)[C@H](C)C[C@@H]5C)[H])[H])[H])[H])O[C@H](C[C@@H]6O[C@@]([C@H](C(O)=O)C)([C@@H](C)CC6)[H])C[C@@H](OC)[C@H]2C

• Molecular Formula:

  C40H68O11

• Molecular Weight:

  724.96

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  28380-24-7