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Imofinostat

CAT: 0931-T16131-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T16131-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1338320-94-7
Target
Apoptosis, Cell Cycle Arrest, Akt, HDAC
Related Pathways
Chromatin/Epigenetic, Cytoskeletal Signaling, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, PI3K/Akt/mTOR signaling, Apoptosis
Bioactivity
Imofinostat (MPT0E028) is a selective, orally available pan-HDAC inhibitor with IC50 values of 53.0/106.2/29.5 nM against HDAC1/HDAC2/HDAC6 in HCT116 cells. In B-cell lymphoma, Imofinostat induces cell cycle arrest and apoptosis whilst inhibiting Akt phosphorylation, demonstrating anticancer activity across multiple tumour types.
Smiles
ONC(=O)\C=C\c1ccc2N(CCc2c1)S(=O)(=O)c1ccccc1
Molecular Formula
C17H16N2O4S
Molecular Weight
344.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-124295-01Imofinostat
A18982-50Imofinostat (MPT0E028) 50mg
A18982-10Imofinostat (MPT0E028) 10mg
A18982-100Imofinostat (MPT0E028) 100mg
A18982-25Imofinostat (MPT0E028) 25mg
A18982-5Imofinostat (MPT0E028) 5mg

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