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Doxifluridine

CAT: 0931-T1600-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0931-T1600-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3094-09-5
Target
DNA/RNA Synthesis, Nucleoside Antimetabolite/Analog
Related Pathways
Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Purity
0.9996
Bioactivity
Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.
Smiles
O[C@H]1[C@@H](O[C@H](C)[C@H]1O)N2C(=O)NC(=O)C(F)=C2
Molecular Formula
C9H11FN2O5
Molecular Weight
246.19
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
B2092-5000Doxifluridine
CS-T-103652Doxifluridine-13C5
HY-B0021SDoxifluridine-d2

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