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Gelsevirine

CAT: 0804-HY-N3940-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N3940-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gelsevirine is the major alkaloid in Gelsemium elegans with potent anxiolytic effects. The anxiolytic mechanism of Gelsevirine may be involved in the agonist action of the glycine receptor in the brain. Gelsevirine has anti-proliferation activity with IC50 values of 1.41 mM and 1.22 mM for SW480 cells and MGC80-3 cells, respectively[1][2][3].
CAS Number
38990-03-3
UNSPSC
12352005
Target
Others
Type
Natural Products
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gelsevirine.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1[C@]([C@H](OC2)C[C@@H]3[C@@]2([H])[C@@]4([H])N5C)(C6=CC=CC=C6N1OC)[C@]4([H])[C@]3(C5)C=C
Molecular Formula
C21H24N2O3
Molecular Weight
352.43
References & Citations
[1]Hua-Hai Zhang, et al. Characterization of Gelsevirine Metabolites in Rat Liver S9 by Accurate Mass Measurements Using High-Performance Liquid chromatography/quadrupole-time-of-flight Mass Spectrometry. Rapid Commun Mass Spectrom. 2019 Jul 30;33 (14) :1179-1184.|[2]Ming Liu, et al. The Active Alkaloids of Gelsemium Elegans Benth. Are Potent Anxiolytics. Psychopharmacology (Berl) . 2013 Feb;225 (4) :839-51.|[3]HUANG Jing, et al. Cytotoxic effects of alkaloidal compounds from Gelsemium elegans Benth on the tumor cells of digestive system in vitro. Strait Pharmaceutical Journal, 2010 , 22 (3) :197-200.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
MBS3611786-01Gelsevirine

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