Lestaurtinib

• Target :

  Trk receptor|||FLT|||Apoptosis|||JAK|||STAT

• Related Pathways :

  Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors|||Apoptosis|||Stem Cells|||Chromatin/Epigenetic

• Purity :

  0.9917

• Bioactivity :

  Lestaurtinib (CEP 701) is an orally available and selective inhibitor of FMS-like tyrosine kinase-3 (FLT3, IC50: 0.9 nM), which inhibits FLT3 autophosphorylation in vitro.Lestaurtinib promotes the expression of c-MYC, inhibits the phosphorylation of RPTKs, and has high affinity for TrkA and JAK2. Lestaurtinib promotes c-MYC expression, inhibits phosphorylation of RPTKs, has a high affinity for TrkA and JAK2, induces apoptosis and cell growth arrest, and can be used to study leukemia.

• Smiles :

  C[C@]12N3C=4C=5N(C=6C(C5C7=C(C4C=8C3=CC=CC8)CNC7=O)=CC=CC6)[C@](O1)(C[C@@]2(CO)O)[H]

• Molecular Formula :

  C26H21N3O4

• Molecular Weight :

  439.46

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  111358-88-4