Rebamipide

• Target :

  Prostaglandin Receptor|||Free radical scavengers|||COX

• Related Pathways :

  Immunology/Inflammation|||Oxidation-Reduction|||GPCR/G Protein|||Neuroscience

• Purity :

  0.999

• Bioactivity :

  Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense.

• Smiles :

  OC(=O)C(CC1=CC(=O)NC2=C1C=CC=C2)NC(=O)C1=CC=C(Cl)C=C1

• Molecular Formula :

  C19H15ClN2O4

• Molecular Weight :

  370.79

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  90098-04-7