Rebamipide

• Target:

  Prostaglandin Receptor|||Free radical scavengers|||COX

• Related Pathways:

  Immunology/Inflammation|||Oxidation-Reduction|||GPCR/G Protein|||Neuroscience

• Purity:

  0.999

• Bioactivity:

  Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense.

• Smiles:

  OC (=O) C (CC1=CC (=O) NC2=C1C=CC=C2) NC (=O) C1=CC=C (Cl) C=C1

• Molecular Formula:

  C19H15ClN2O4

• Molecular Weight:

  370.79

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  90098-04-7