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Rebamipide

CAT: 0931-T1562Size: 1 gDry Ice: NoHazardous: No
CAT#:0931-T1562Size:1 g
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
90098-04-7
Target
Prostaglandin Receptor|||Free radical scavengers|||COX
Related Pathways
Immunology/Inflammation|||Oxidation-Reduction|||GPCR/G Protein|||Neuroscience
Purity
0.999
Bioactivity
Rebamipide (OPC12759) is a quinolinone derivative with anti-ulcer and anti-inflammatory activities. Rebamipide induces cyclooxygenase 2 (COX2) synthesis which results in an increase in endogenous prostaglandin synthesis in the gastric mucosa. This agent also inhibits H. pylori-induced production of tumor necrosis factor (TNF) alpha and subsequent inflammation of the gastric mucosa. In addition, rebamipide scavenges oxygen-derived free radicals that potentially cause mucosal injury, and stimulates prostaglandin EP4 receptor gene expression followed by mucous secretion, thereby enhancing the gastric mucosal defense.
Smiles
OC(=O)C(CC1=CC(=O)NC2=C1C=CC=C2)NC(=O)C1=CC=C(Cl)C=C1
Molecular Formula
C19H15ClN2O4
Molecular Weight
370.79
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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