Dolastatin 15

• Target:

  Apoptosis|||ADC Cytotoxin|||Microtubule Associated

• Related Pathways:

  Cytoskeletal Signaling|||Antibody-drug Conjugate/ADC Related|||Apoptosis

• Bioactivity:

  Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces cell cycle arrest and apoptosis in multiple myeloma cells.

• Smiles:

  COC1=CC (=O) N ([C@H]1Cc1ccccc1) C (=O) [C@@H] (OC (=O) [C@@H]1CCCN1C (=O) [C@@H]1CCCN1C (=O) [C@H] (C (C) C) N (C) C (=O) [C@@H] (NC (=O) [C@H] (C (C) C) N (C) C) C (C) C) C (C) C |t:2, @:48, @@:36|

• Molecular Formula:

  C45H68N6O9

• Molecular Weight:

  837.072

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  123884-00-4