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CLP257

CAT: 0931-T14984-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T14984-07Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1181081-71-9
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.995
Bioactivity
CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it also modulates plasmalemmal KCC2 protein turnover post-translationally. CLP257 restores impaired Cl− transport in neurons with diminished KCC2 activity.
Smiles
Oc1cc(F)ccc1\C=C1/SC(=NC1=O)N1CCCCN1
Molecular Formula
C14H14FN3O2S
Molecular Weight
307.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Clp257

a chloride extrusion enhancer that targets KCC2; structure in first source

CAS Number1181081-71-9
PubChem CID44188931
IUPAC Name(5Z)-2-(diazinan-1-yl)-5-[(4-fluoro-2-hydroxyphenyl)methylidene]-1,3-thiazol-4-one
Molecular FormulaC14H14FN3O2S
Molecular Weight307.35
XLogP2.5
Topological Polar Surface Area90.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count21
Formal Charge0
Complexity483
SMILES
C1CCN(NC1)C2=NC(=O)/C(=C/C3=C(C=C(C=C3)F)O)/S2
InChI
InChI=1S/C14H14FN3O2S/c15-10-4-3-9(11(19)8-10)7-12-13(20)17-14(21-12)18-6-2-1-5-16-18/h3-4,7-8,16,19H,1-2,5-6H2/b12-7-
InChIKey
SKCADXVKQRCWTR-GHXNOFRVSA-N
Chemical Structure
2D Structure
2D structure of Clp257
CAS: 1181081-71-9
CID: 44188931
Formula: C14H14FN3O2S
MW: 307.35
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight307.35
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass307.07907603
Monoisotopic Mass307.07907603
Topological Polar Surface Area90.2 Ų
Heavy Atom Count21
Formal Charge0
Complexity483
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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