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Deucravacitinib

CAT: 0931-T14687-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T14687-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1609392-27-9
Target
Interleukin, JAK, Tyrosine Kinases, IFNAR
Related Pathways
Chromatin/Epigenetic, Immunology/Inflammation, Angiogenesis, Stem Cells, Tyrosine Kinase/Adaptors, JAK/STAT signaling
Purity
>99.99%
Bioactivity
Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor for the treatment of autoimmune diseases. It blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain, inhibiting IL-12/23 and type I IFN pathways. It selectively binds to the TYK2 pseudokinase (JH2) domain with an IC50 of 1.0 nM.
Smiles
[2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC
Molecular Formula
C20H19D3N8O3
Molecular Weight
425.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
B8781-50Deucravacitinib
CS-O-65082Deucravacitinib-d3
MBS5812935Deucravacitinib HCl
CS-O-65081Deucravacitinib-d6
HY-117287ADeucravacitinib (hydrochloride)
AR-B07462-01Deucravacitinib D3
CS-EO-03258N-Nitroso Deucravacitinib
RM-D223007-01Deucravacitinib Impurity 7
RM-D223016-01Deucravacitinib Impurity 16
RM-D223026-01Deucravacitinib Impurity 26

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