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Biperiden Hydrochloride

CAT: 0931-T14614-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T14614-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1235-82-1
Target
Others, AChR
Related Pathways
Others, Neuroscience
Bioactivity
Biperiden Hydrochloride (KL 373 Hydrochloride) is an antiparkinsonian agent, which is the selective central M1 cholinoreceptors blocker and it is used for the adjunctive treatment of all forms of Parkinson's disease (postencephalitic, idiopathic, and arteriosclerotic) [1]. Target: M1 receptors Biperiden is an antiparkinsonian agent of the anticholinergic type. Biperiden has an atropine-like blocking effect on all peripheral structures which are parasympathetic-innervate and it also has a prominent central blocking effect on M1 receptors[2]. Biperiden (0.11 mg/kg), benactyzine (0.3 mg/kg), caramiphen (10 mg/kg), procyclidine (3 mg/kg), and trihexyphenidyl (0.12 mg/kg) separately and each in combination with physostigmine (0.1 mg/kg) is to make a comparative assessment of potential cognitive effects. The results showed that benactyzine, caramiphen, and trihexyphenidyl reduced rats' innate preference for novelty. Whereas biperiden and procyclidine did not [3]. Clinical indications: parkinsonism FDA Approved Date: Toxicity: Drowsiness; vertigo; headache; dizziness
Smiles
Cl.OC(C=1C=CC=CC1)(CCN2CCCCC2)C3CC4C=CC3C4
Molecular Formula
C21H30ClNO
Molecular Weight
347.92
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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