BI-0252

• Target:

  E1/E2/E3 Enzyme|||MDM-2/p53|||Others

• Related Pathways:

  Ubiquitination|||Others|||Apoptosis

• Bioactivity:

  BI-0252 is an inhibitor of MDM2-p53 (IC50:4 nM) . BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft. And it concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis.

• Smiles:

  C(N1[C@@]2([C@H]([C@]3([C@@]1(C[C@@H](N3)C4=CC=C(C(O)=O)C=C4)[H])[H])C5=C(F)C(Cl)=CC=C5)C=6C(NC2=O)=CC(Cl)=CC6)C7CC7

• Molecular Formula:

  C30H26Cl2FN3O3

• Molecular Weight:

  566.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1818291-27-8