BI-0252

CAT: 0931-MF-0032270-01Size: 25 mgDry Ice: NoHazardous: No

CAT#:0931-MF-0032270-01Size:25 mg

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AVAILABILITY: InStock

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1818291-27-8

Target

E1/E2/E3 Enzyme|||MDM-2/p53|||Others

Related Pathways

Ubiquitination|||Others|||Apoptosis

Bioactivity

BI-0252 is an inhibitor of MDM2-p53 (IC50:4 nM) . BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft. And it concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis.

Smiles

C(N1[C@@]2([C@H]([C@]3([C@@]1(C[C@@H](N3)C4=CC=C(C(O)=O)C=C4)[H])[H])C5=C(F)C(Cl)=CC=C5)C=6C(NC2=O)=CC(Cl)=CC6)C7CC7

Molecular Formula

C30H26Cl2FN3O3

Molecular Weight

566.45

Shipping Conditions

Cool pack

Storage Temperature

-20°C

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MBS3845265-01	BI-0252
A20824-10	BI-0252 10mg
A20824-25	BI-0252 25mg
A20824-5	BI-0252 5mg
A20824-50	BI-0252 50mg
A20824-1	BI-0252 1mg
A20824-100	BI-0252 100mg
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BI-0252

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