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AZM475271

CAT: 0931-T14487-02Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T14487-02Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
476159-98-5
Target
Others, Src, Apoptosis
Related Pathways
Apoptosis, Angiogenesis, Others, Tyrosine Kinase/Adaptors
Purity
0.9978
Bioactivity
AZM475271 is a potent and selective inhibitor of Src kinase (IC50: 5 nM) .
Smiles
COc1ccc(Cl)c(Nc2ncnc3cc(OCC4CCN(C)CC4)c(OC)cc23)c1
Molecular Formula
C23H27ClN4O3
Molecular Weight
442.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

M-475271

Src Kinase Inhibitor M475271 is an inhibitor of Src tyrosine kinase, with potential antineoplastic activity. Upon administration, Src kinase inhibitor M-475271 targets and binds to Src kinase. This inhibits Src-mediated signaling and the proliferation of tumor cells overexpressing Src. Src tyrosine kinase, a non-receptor tyrosine kinase upregulated in many tumor cell types, plays an important role in tumor cell proliferation, motility, invasiveness and survival.

CAS Number476159-98-5
PubChem CID5330175
IUPAC NameN-(2-chloro-5-methoxyphenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine
Molecular FormulaC23H27ClN4O3
Molecular Weight442.9
XLogP4.7
Topological Polar Surface Area68.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count31
Formal Charge0
Complexity551
SMILES
CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=CC(=C4)OC)Cl)OC
InChI
InChI=1S/C23H27ClN4O3/c1-28-8-6-15(7-9-28)13-31-22-12-19-17(11-21(22)30-3)23(26-14-25-19)27-20-10-16(29-2)4-5-18(20)24/h4-5,10-12,14-15H,6-9,13H2,1-3H3,(H,25,26,27)
InChIKey
WPOXAFXHRJYEIC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of M-475271
CAS: 476159-98-5
CID: 5330175
Formula: C23H27ClN4O3
MW: 442.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight442.9
XLogP34.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass442.1771684
Monoisotopic Mass442.1771684
Topological Polar Surface Area68.7 Ų
Heavy Atom Count31
Formal Charge0
Complexity551
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-13561-01AZM475271
A16241-50AZM475271 50mg
A16241-10AZM475271 10mg
A16241-100AZM475271 100mg
A16241-5AZM475271 5mg
A16241-2AZM475271 2mg
A16241-10mM-DAZM475271 10mM * 1mL in DMSO

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