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Apricitabine

CAT: 0931-T14313-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T14313-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
160707-69-7
Target
HIV Protease, Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis
Related Pathways
Microbiology/Virology, Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Proteases/Proteasome
Purity
>99.99%
Bioactivity
Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β and γ with Ki values of 300 μM, 12 μM and 112.25 μM, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance.
Smiles
O=C1N([C@@H]2S[C@H](CO)OC2)C=CC(N)=N1
Molecular Formula
C8H11N3O3S
Molecular Weight
229.26
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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MBS130032-01Apricitabine
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KGA70769-01(-) -2'-Deoxy-3'-oxa-4'-thiocytidine (apricitabine)
D245520trans-2'-Deoxy-3'-oxa-4'-thiocytidine (Apricitabine)

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