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Aphidicolin

CAT: 0931-T14304Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T14304Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
38966-21-1
Target
DNA/RNA Synthesis, Others, HSV, Apoptosis, Antibiotic, Virus Protease
Related Pathways
Microbiology/Virology, Apoptosis, DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Others
Purity
>99.99%
Bioactivity
Aphidicolin, an antibiotic derived from the mold Cephalosporium aphidicola, is a potent inhibitor of DNA (deoxyribonucleic acid) synthesis, effectively hindering the proliferation of herpes simplex virus[2]. It targets DNA polymerase α and δ, disrupting mitotic cell division by affecting DNA polymerase activity[1]. Additionally, aphidicolin enhances apoptosis when combined with arabinosyl nucleosides in a human promyelocytic leukemia cell line[3].
Smiles
[H][C@]12C[C@]3([H])C[C@]1(CC[C@]3(O)CO)[C@@]1(C)CC[C@@H](O)[C@@](C)(CO)[C@]1([H])CC2
Molecular Formula
C20H34O4
Molecular Weight
338.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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