Aphidicolin

• Target :

  DNA/RNA Synthesis|||Others|||HSV|||Apoptosis|||Antibiotic|||Virus Protease

• Related Pathways :

  Microbiology/Virology|||Apoptosis|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint|||Others

• Purity :

  >99.99%

• Bioactivity :

  Aphidicolin, an antibiotic derived from the mold Cephalosporium aphidicola, is a potent inhibitor of DNA (deoxyribonucleic acid) synthesis, effectively hindering the proliferation of herpes simplex virus[2]. It targets DNA polymerase ? and ?, disrupting mitotic cell division by affecting DNA polymerase activity[1]. Additionally, aphidicolin enhances apoptosis when combined with arabinosyl nucleosides in a human promyelocytic leukemia cell line[3].

• Smiles :

  [H][C@]12C[C@]3([H])C[C@]1(CC[C@]3(O)CO)[C@@]1(C)CC[C@@H](O)[C@@](C)(CO)[C@]1([H])CC2

• Molecular Formula :

  C20H34O4

• Molecular Weight :

  338.48

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  38966-21-1