Toceranib

• Target:

  VEGFR|||c-Kit|||PDGFR

• Related Pathways:

  Angiogenesis|||Tyrosine Kinase/Adaptors

• Purity:

  0.9762

• Bioactivity:

  Toceranib (PHA 291639E) phosphate is an orally active inhibitor of tyrosine kinase (RTK) receptor, and it potently inhibits PDGFR, VEGFR, and Kit (with Kis of 5 and 6 nM for PDGFR? and Flk-1/KDR, respectively), has antitumor and antiangiogenic activity.

• Smiles:

  Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NCCN1CCCC1

• Molecular Formula:

  C22H25FN4O2

• Molecular Weight:

  396.46

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  356068-94-5