cis-11,14-Eicosadienoic acid methyl ester

cis-11,14-Eicosadienoic acid methyl ester

• CAS Number: 61012-46-2
• UNSPSC Description: cis-11,14-Eicosadienoic acid methyl ester is a more lipid soluble form of the ω-6 C20-2 fatty acid 11(Z),14(Z)-eicosadienoic acid, a naturally occurring PUFA. 11(Z),14(Z)-Eicosadienoic acid competitively inhibits inosine 5’-monophosphate dehydrogenase (Ki=3.1 μM) and inhibits the binding of LTB4 to its receptor on neutrophils (Ki=3.0 μM). Also, serum levels of eicosadienoic acids negatively correlate with degree of sleep disturbance.3 Eicosadienoic acids are converted by desaturases, in vivo, to eicosatrienoic acids, which are potent vasodilators.
• Target Antigen: Endogenous Metabolite
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/cis-11-14-eicosadienoic-acid-methyl-ester.html
• Smiles: CCCCC/C=C\C/C=C\CCCCCCCCCC(OC)=O
• Molecular Weight: 322.53
• References & Citations: [1]Yagaloff, et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins, Leukot. Essent. Fatty Acids 52(5), 293-297 (1995).
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported