Paradol

• Description :

  Paradol is a pungent phenolic substance found in ginger and other Zingiberaceae plants. Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX) -2 active site.

• CAS Number :

  [27113-22-0]

• Product Name Alternative :

  [6]-Gingerone; [6]-Paradol

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  COX

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Paradol.html

• Concentration :

  10mM

• Purity :

  99.87

• Solubility :

  DMSO : ≥ 140 mg/mL

• Smiles :

  COC1=C(O)C=CC(CCC(CCCCCCC)=O)=C1

• Molecular Formula :

  C17H26O3

• Molecular Weight :

  278.39

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]van Breemen RB, et al. Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale) . Fitoterapia. 2011 Jan;82 (1) :38-43.|[2]Keum YS, et al. Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells. Cancer Lett. 2002 Mar 8;177 (1) :41-7.|[3]Gaire BP, et al. Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia. PLoS One. 2015 Mar 19;10 (3) :e0120203.|[4]Setoguchi S, et al. Pharmacokinetics of Paradol Analogues Orally Administered to Rats. J Agric Food Chem. 2016 Mar 9;64 (9) :1932-7.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  COX-2