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Peruvoside

CAT: 0931-T126270-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T126270-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1182-87-2
Target
Apoptosis, Autophagy, STAT, JNK, EGFR, ATPase, PI3K, Src, Wnt/beta-catenin
Related Pathways
Cytoskeletal Signaling, Membrane transporter/Ion channel, MAPK, Stem Cells, JAK/STAT signaling, PI3K/Akt/mTOR signaling, Apoptosis, Tyrosine Kinase/Adaptors, Autophagy, Angiogenesis
Bioactivity
Peruvoside (Encordin) is a natural cardiac glycoside that inhibits Na+/K+-ATPase to increase myocardial contractility; causes cell cycle arrest in leukemia stem cells at the G2/M phase, and; inhibits NSCLC cell growth as a Src inhibitor; and induces apoptosis in cancer cells through MAPK Wnt / β-catenin and PI3K / AKT / mTOR .
Smiles
C(=O)[C@@]12[C@@]3([C@]([C@]4(O)[C@](C)(CC3)[C@H](CC4)C=5COC(=O)C5)(CC[C@@]1(C[C@@H](O[C@H]6[C@@H](O)[C@H](OC)[C@@H](O)[C@H](C)O6)CC2)[H])[H])[H]
Molecular Formula
C30H44O9
Molecular Weight
548.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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