Neriifolin

• Target :

  Apoptosis|||ATPase|||Autophagy|||ATG

• Related Pathways :

  Autophagy|||Membrane transporter/Ion channel|||Apoptosis

• Bioactivity :

  Neriifolin (17?-Neriifolin), a cardiac glycoside extracted from the unripe fruit of Cerbera manghas, is a Na+K+-ATPase inhibitor with anticancer activity that inhibits cell proliferation by suppressing HOXA9-dependent gene expression and inducing apoptosis in the human acute myeloid cell line, THP-1. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells and can be used in prostate cancer research.

• Smiles :

  O[C@@]12[C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@@H](O[C@H]5[C@@H](O)[C@H](OC)[C@@H](O)[C@H](C)O5)CC4)[H])(CC[C@]1(C)[C@H](CC2)C6=CC(=O)OC6)[H])[H]

• Molecular Formula :

  C30H46O8

• Molecular Weight :

  534.68

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  466-07-9