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PF-04634817

CAT: 0931-T12419L-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T12419L-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1228111-63-4
Target
CCR
Related Pathways
Microbiology/Virology|||GPCR/G Protein|||Immunology/Inflammation
Bioactivity
PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 antagonist. It also has comparable human and rodent CCR2 potency (rat IC50=20.8 nM) . PF-0463481 shows 10-20 fold less rodent CCR5 potency (rat IC50=470 nM) .
Smiles
C(=O)([C@]1([C@@H](C)C)C[C@H](N[C@@H]2[C@H](OC)COCC2)CC1)N3[C@@]4(CN([C@](C3)(C4)[H])C=5C=C(C(F)(F)F)N=CN5)[H]
Molecular Formula
C25H36F3N5O3
Molecular Weight
511.58
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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