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Rofecoxib

CAT: 0931-T1185-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T1185-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
162011-90-7
Target
COX
Related Pathways
Neuroscience, Immunology/Inflammation
Purity
0.9994
Bioactivity
Rofecoxib (MK 966) binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of phenyl-furanone with anti-inflammatory, antipyretic and analgesic properties and potential antineoplastic properties. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2.
Smiles
O=C1C(=C(CO1)C2=CC=C(S(C)(=O)=O)C=C2)C3=CC=CC=C3
Molecular Formula
C17H14O4S
Molecular Weight
314.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
B1454-100Rofecoxib

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