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Propoxur

CAT: 0804-HY-B0916-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0916-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests[1][2][3].
CAS Number
114-26-1
UNSPSC
12352005
Hazard Statement
H300+H330, H311
Target
Cholinesterase (ChE) ; ERK; Insecticide; Keap1-Nrf2; MMP; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Propoxur.html
Concentration
10mM
Purity
99.43
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(C)OC1=CC=CC=C1OC(NC)=O
Molecular Formula
C11H15NO3
Molecular Weight
209.24
Precautions
H300+H330, H311
References & Citations
[1]Shi Y, et al. Propoxur enhances MMP-2 expression and the corresponding invasion of human breast cancer cells via the ERK/Nrf2 signaling pathway. Oncotarget. 2017 Jul 7;8 (50) :87107-87123.|[2]Maran E, et al. Effects of aldicarb and propoxur on cytotoxicity and lipid peroxidation in CHO-K1 cells. Food Chem Toxicol. 2010 Jun;48 (6) :1592-6.|[3]Mohamadin A M, et al. Protective effects of Nigella sativa oil on propoxur-induced toxicity and oxidative stress in rat brain regions[J]. Pesticide biochemistry and physiology, 2010, 98 (1) : 128-134.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; MMP-2

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