L002

• Target:

  STAT|||Epigenetic Reader Domain|||Histone Acetyltransferase

• Related Pathways:

  JAK/STAT signaling|||Stem Cells|||Chromatin/Epigenetic

• Purity:

  0.9859

• Bioactivity:

  L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 ?M, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By blocking histone acetylation, p53 acetylation, and STAT3 activation, L002 shows potential in the treatment of hypertension?induced cardiac hypertrophy and fibrogenesis.

• Smiles:

  COc1ccc(cc1)S(=O)(=O)ON=C1C=C(C)C(=O)C(C)=C1

• Molecular Formula:

  C15H15NO5S

• Molecular Weight:

  321.35

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  321695-57-2