L002

CAT: 0931-T11807-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-T11807-01Size:2 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
321695-57-2
Target
STAT|||Epigenetic Reader Domain|||Histone Acetyltransferase
Related Pathways
JAK/STAT signaling|||Stem Cells|||Chromatin/Epigenetic
Purity
0.9859
Bioactivity
L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 ?M, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By blocking histone acetylation, p53 acetylation, and STAT3 activation, L002 shows potential in the treatment of hypertension?induced cardiac hypertrophy and fibrogenesis.
Smiles
COc1ccc(cc1)S(=O)(=O)ON=C1C=C(C)C(=O)C(C)=C1
Molecular Formula
C15H15NO5S
Molecular Weight
321.35
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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