JDTic

CAT: 0931-MF-0022670-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0022670-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
361444-66-8
Target
Opioid Receptor|||JAK
Related Pathways
Angiogenesis|||Chromatin/Epigenetic|||Stem Cells|||Neuroscience|||JAK/STAT signaling|||Endocrinology/Hormones|||Tyrosine Kinase/Adaptors|||GPCR/G Protein
Bioactivity
JDTic, a 4-phenylpiperidine derivative distantly related to analgesics like meperidine and ketobemidone and more closely to the mu opioid antagonist alvimopan, exhibits a notably long duration of action, maintaining effects in animals for weeks following a single dose. This duration is not due to irreversible binding to the kappa opioid receptor but rather to altered activity of c-Jun N-terminal kinases. As a highly selective antagonist for the ?-opioid receptor, without influencing the ?- or ?-opioid receptors, JDTic has shown potential in animal studies for producing antidepressant and anxiolytic effects. It also demonstrates promise in treating addiction to substances such as cocaine and morphine, distinguishing itself structurally from other kappa antagonists like norbinaltorphimine.
Smiles
C[C@@]1([C@@H](C)CN(C[C@@H](NC(=O)[C@H]2CC=3C(CN2)=CC(O)=CC3)C(C)C)CC1)C4=CC(O)=CC=C4
Molecular Formula
C28H39N3O3
Molecular Weight
465.63
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Alternative Products

CatalogName
A3517-5JDTic
A11468-25JDTic 25mg
A11468-1JDTic 1mg
MBS386795-01JDTic dihydrochloride
A11468-50JDTic 50mg
A11468-5JDTic 5mg
A3518-50JDTic 2HCl
A11468-10JDTic 10mg
HY-10487-01JDTic (dihydrochloride)
A11469-5JDTic dihydrochloride 5mg

Popular Products