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J22352

CAT: 0931-T11701Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T11701Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2252395-44-9
Target
Caspase, HDAC
Related Pathways
DNA Damage/DNA Repair, Proteases/Proteasome, Apoptosis, Chromatin/Epigenetic
Bioactivity
J22352, a PROTAC (proteolysis-targeting chimeras) -like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in glioblastoma by promoting HDAC6 degradation. It does so by inhibiting autophagy and stimulating the antitumor immune response, further restoring host antitumor activity through the reduction of PD-L1's immunosuppressive activity.
Smiles
ONC(=O)c1ccc(Cn2c3ccccc3c(=O)n(CCc3ccccc3)c2=O)cc1
Molecular Formula
C24H21N3O4
Molecular Weight
415.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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CQD39544-01J22352
A19174-50J22352 50mg
A19174-10J22352 10mg
A19174-5J22352 5mg
A19174-100J22352 100mg
A19174-2J22352 2mg

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