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Isofistularin-3

CAT: 931-T11682-01Size: 100 mgDry Ice: NoHazardous: No
100 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Autophagy|||ADC Cytotoxin|||Apoptosis|||DNA Methyltransferase
Related Pathways
Apoptosis|||Autophagy|||Antibody-drug Conjugate/ADC Related|||Chromatin/Epigenetic
Bioactivity
Isofistularin-3, a direct DNA-competitive DNMT1 inhibitor with an IC50 of 13.5 ?M, functions as a DNA demethylating agent, leading to cell cycle arrest and increased sensitivity to TRAIL in cancer cells. Additionally, it can be employed as an ADC cytotoxin.
Smiles
COC1=C(Br)[C@H](O)[C@@]2(ON=C(C(NC[C@H](O)COC3=C(Br)C=C([C@H](O)CNC(C4=NO[C@]5(C4)C=C(Br)C(OC)=C(Br)[C@H]5O)=O)C=C3Br)=O)C2)C=C1Br
Molecular Formula
C31H30Br6N4O11
Molecular Weight
1114.01
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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