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GLPG1205

CAT: 0931-T11411-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T11411-05Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1445847-37-9
Target
GPCR
Related Pathways
Endocrinology/Hormones, GPCR/G Protein
Purity
0.9994
Bioactivity
GLPG1205 is a potent, orally active GPR84 (G protein-coupled receptor) antagonist with anti-inflammatory activity. GLPG1205 shows good PK/PD characteristics and can be used to study pulmonary fibrosis.
Smiles
O=c1nc(OC[C@@H]2COCCO2)cc2-c3ccc(cc3CCn12)C#CC1CC1
Molecular Formula
C22H22N2O4
Molecular Weight
378.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Glpg-1205

GLPG-1205 is under investigation in clinical trial NCT03725852 (A Clinical Study to Test How Effective and Safe GLPG1205 is for Patients With Idiopathic Pulmonary Fibrosis (IPF)).

CAS Number1445847-37-9
PubChem CID71616860
IUPAC Name9-(2-cyclopropylethynyl)-2-[[(2S)-1,4-dioxan-2-yl]methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
Molecular FormulaC22H22N2O4
Molecular Weight378.4
XLogP2.4
Topological Polar Surface Area60.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity757
SMILES
C1CC1C#CC2=CC3=C(C=C2)C4=CC(=NC(=O)N4CC3)OC[C@@H]5COCCO5
InChI
InChI=1S/C22H22N2O4/c25-22-23-21(28-14-18-13-26-9-10-27-18)12-20-19-6-5-16(4-3-15-1-2-15)11-17(19)7-8-24(20)22/h5-6,11-12,15,18H,1-2,7-10,13-14H2/t18-/m0/s1
InChIKey
IRBAWVGZNJIROV-SFHVURJKSA-N
Chemical Structure
2D Structure
2D structure of Glpg-1205
CAS: 1445847-37-9
CID: 71616860
Formula: C22H22N2O4
MW: 378.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight378.4
XLogP32.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass378.15795719
Monoisotopic Mass378.15795719
Topological Polar Surface Area60.4 Ų
Heavy Atom Count28
Formal Charge0
Complexity757
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-135303-01GLPG1205

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