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GGTI298

CAT: 0931-T11397-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T11397-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
180977-44-0
Target
Apoptosis, Others
Related Pathways
Others, Apoptosis
Bioactivity
GGTI298, a CAAZ peptidomimetic and potent geranylgeranyltransferase I (GGTase I) inhibitor, efficiently blocks the processing of geranylgeranylated Rap1A while exerting minimal impact on the processing of farnesylated Ha-Ras. The inhibitor displays in vivo IC50 values of 3 μM for Rap1A and >20 μM for Ha-Ras, respectively.
Smiles
C(N[C@H](C(OC)=O)CC(C)C)(=O)C1=C(C=C(NC[C@H](CS)N)C=C1)C=2C3=C(C=CC2)C=CC=C3
Molecular Formula
C27H33N3O3S
Molecular Weight
479.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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