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Forodesine hydrochloride

CAT: 0931-T11313-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0931-T11313-01Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
284490-13-7
Target
Apoptosis, Nucleoside Antimetabolite/Analog, Others
Related Pathways
Cell Cycle/Checkpoint, Others, DNA Damage/DNA Repair, Apoptosis
Bioactivity
Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly potent purine nucleoside phosphorylase (PNP) inhibitor, demonstrating IC50 values between 0.48 to 1.57 nM across human, mouse, rat, monkey, and dog PNP.
Smiles
Cl.OC[C@H]1N[C@H]([C@H](O)[C@@H]1O)c1c[nH]c2c1[nH]cnc2=O
Molecular Formula
C11H15ClN4O4
Molecular Weight
302.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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