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F-1

CAT: 0931-T11254-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T11254-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2244775-31-1
Target
ROS Kinase, ALK, ROS
Related Pathways
Tyrosine Kinase/Adaptors, Immunology/Inflammation, Angiogenesis
Purity
0.995
Bioactivity
F-1 is IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. F-1 is a potent ALK and ROS1 dual inhibitor, suppresses phospho-ALK and its relative downstream signaling pathways.
Smiles
COc1nc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCN(C)CC1
Molecular Formula
C22H27ClN8O3S
Molecular Weight
519.02
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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